{Reference Type}: Journal Article
{Title}: Coordinating the cytoskeleton and endocytosis for regulated plasma membrane growth in the early Drosophila embryo.
{Author}: Lee DM;Harris TJ;
{Journal}: Bioarchitecture
{Volume}: 4
{Issue}: 2
{Year}: Mar-Apr 2014
暂无{DOI}: 10.4161/bioa.28949
{Abstract}: Plasma membrane organization is under the control of cytoskeletal networks and endocytic mechanisms, and a growing literature is showing how closely these influences are interconnected. Here, we review how plasma membranes are formed around individual nuclei of the syncytial Drosophila embryo. Specifically, we outline the pathways that promote and maintain the growth of pseudocleavage and cellularization furrows, as well as specific pathways that keep furrow growth in check. This system has become important for studies of actin regulators, such as Rho1, Diaphanous, non-muscle myosin II and Arp2/3, and endocytic regulators, such as a cytohesin Arf-GEF (Steppke), clathrin, Amphiphysin and dynamin. More generally, it provides a model for understanding how cytoskeletal-endocytic cross-talk regulates the assembly of a cell.