{Reference Type}: Journal Article
{Title}: Sperm-induced Ca2+ release during egg activation in mammals.
{Author}: Kashir J;Nomikos M;Lai FA;Swann K;
{Journal}: Biochem Biophys Res Commun
{Volume}: 450
{Issue}: 3
{Year}: Aug 2014 1
{Factor}: 3.322
{DOI}: 10.1016/j.bbrc.2014.04.078
{Abstract}: This review discusses the role that the sperm-specific phospholipase C zeta (PLCζ) is proposed to play during the fertilization of mammalian eggs. At fertilization, the sperm initiates development by causing a series of oscillations in cytosolic concentrations of calcium [Ca(2)] within the egg. PLCζ mimics the sperm at fertilization, causing the same pattern of Ca(2+) release as seen at fertilization. Introducing PLCζ into mouse eggs also mimics a number of other features of the way in which the fertilizing sperm triggers Ca(2+) oscillations. We discuss the localization of PLCζ within the egg and present a hypothesis about the localization of PLCζ within the sperm before the initiation of fertilization.