{Reference Type}: Journal Article
{Title}: [Application of vancomycin powder into the wound during spine surgery: systematic review and meta-analysis].
{Author}: Alcalá-Cerra G;Paternina-Caicedo AJ;Moscote-Salazar LR;Gutiérrez-Paternina JJ;Niño-Hernández LM;
{Journal}: Rev Esp Cir Ortop Traumatol
{Volume}: 58
{Issue}: 3
{Year}: May-Jun 2014
暂无{DOI}: 10.1016/j.recot.2013.10.004
{Abstract}: <B>OBJECTIVE: </B>To determine the effects of applying vancomycin powder within the surgical wound on the risk of surgical infections, pseudo-arthrosis and adverse events, in patients undergoing spinal surgery.<BR><B>METHODS: </B>A meta-analysis was carried out, including controlled studies that evaluated the risk of postoperative infections and/or pseudo-arthrosis in patients undergoing spinal surgery in which vancomycin powder was applied within the surgical wound.<BR><B>RESULTS: </B>were presented as pooled relative risks, with its 95% confidence intervals. Additionally, the frequency of complications attributable to vancomycin was also assessed.<BR><B>RESULTS: </B>A total of six controlled studies (3,379 subjects) were included. Pooled relative risks were: surgical site infection, 0.11 (95%CI: 0.05-0.25; P<.00001), and pseudo-arthrosis, 0.87 (95%CI; 0.34-2.21; P=.77). No statistically significant heterogeneity was found in both analyses. In 1,437 patients treated with vancomycin, there were no recorded vancomycin-related adverse events.<BR><B>CONCLUSIONS: </B>Application of vancomycin powder into the wound was associated with a significantly reduced risk of surgical site infections, without increasing pseudo-arthrosis or adverse events. However, randomized controlled trials are needed, in order to confirm the present results and make recommendations with more certainty.