{Reference Type}: Journal Article
{Title}: Diagnosis of endometrial stromal tumors: a clinicopathologic study of 25 biopsy specimens with identification of problematic areas.
{Author}: Stemme S;Ghaderi M;Carlson JW;
{Journal}: Am J Clin Pathol
{Volume}: 141
{Issue}: 1
{Year}: Jan 2014
{Factor}: 5.4
{DOI}: 10.1309/AJCPXD0TPYSNVI8I
{Abstract}: <B>OBJECTIVE: </B>To assess the difficulties associated with diagnosing endometrial stromal tumors (ESTs) on endometrial biopsy.<BR><B>METHODS: </B>We examined 25 endometrial biopsy specimens from 19 consecutive women diagnosed with either endometrial stromal nodule (n = 3) or endometrial stromal sarcoma (n = 16).<BR><B>RESULTS: </B>Rereview of the biopsy specimens revealed a stromal fragment suspicious for an EST in 16, of which eight had received a benign diagnosis on initial review. Most ESTs had an aglandular stromal fragment that was 5 mm or larger. Stromal fragments of this size were not encountered in the control material. Problematic areas included highly cellular leiomyoma and a lack of attention to the stromal compartment.<BR><B>CONCLUSIONS: </B>Most endometrial stromal tumors present with large aglandular stromal fragments (≥5 mm). These fragments are large enough that difficulties in diagnosis appear to be due to a lack of attention to the stromal compartment.