{Reference Type}: Clinical Trial
{Title}: In vitro gastrointestinal model (TIM) with predictive power, even for infants and children?
{Author}: Havenaar R;Anneveld B;Hanff LM;de Wildt SN;de Koning BA;Mooij MG;Lelieveld JP;Minekus M;
{Journal}: Int J Pharm
{Volume}: 457
{Issue}: 1
{Year}: Nov 2013 30
{Factor}: 6.51
{DOI}: 10.1016/j.ijpharm.2013.07.053
{Abstract}: There is a need for information on the bioavailability in pediatric patients of drugs from manipulated dosage forms when applied in combination with food and/or co-medication under realistic daily practice circumstances. We describe the development, validation and application of a dynamic, computer-controlled in vitro system mimicking the conditions in the upper gastrointestinal tract of neonates, infants and toddlers: TIMpediatric. Paracetamol and diclofenac in age-related food matrices and with esomeprazole co-medication were tested. The experiments showed relevant results on the impact of drug manipulation and co-medication on the availability for absorption of active compounds. Without ethical constraints, alternative approaches for oral dosing and new pediatric formulations can be studied in TIMpediatric with a high predictive value.