{Reference Type}: Case Reports
{Title}: Ovarian pulmonary-type small cell carcinoma: case report and review of the literature.
{Author}: Kurasaki A;Sakurai N;Yamamoto Y;Taoka H;Takahashi K;Kubushiro K;
{Journal}: Int J Gynecol Pathol
{Volume}: 32
{Issue}: 5
{Year}: Sep 2013
{Factor}: 3.326
{DOI}: 10.1097/PGP.0b013e31826d7ea8
{Abstract}: Ovarian pulmonary-type small cell carcinoma is a rare and extremely aggressive neoplasm. We report the occurrence of an ovarian small cell carcinoma of pulmonary type in a 54-year-old woman. She underwent a total abdominal hysterectomy with a bilateral salpingo-oophorectomy and infracolic omentectomy. A diagnosis of stage IIIA pulmonary-type small cell carcinoma was rendered. The tumor appeared to be composed of a solid growth of small cells arranged in sheets and closely packed nests with insular arrangements separated by a fibrous stroma. The tumor cells had hyperchromatic nuclei with inconspicuous nucleoli and scanty cytoplasm. Rosette and rosette-like structures were scattered. Immunohistochemical staining showed positivity for synaptophysin, neural cell adhesion molecule (NCAM), and focally for chromogranin. Cytokeratin and neuron-specific enolase (NSE) were also positive. Over 80% of the tumor cells showed strong reactivity for MIB-1. Electron microscopy showed neuroendocrine granules. She was effectively treated with paclitaxel plus carboplatin after the surgery.