{Reference Type}: Comparative Study
{Title}: High-definition endoscopy with i-Scan for evaluation of small colon polyps: the HiSCOPE study.
{Author}: Basford PJ;Longcroft-Wheaton G;Higgins B;Bhandari P;
{Journal}: Gastrointest Endosc
{Volume}: 79
{Issue}: 1
{Year}: Jan 2014
{Factor}: 10.396
{DOI}: 10.1016/j.gie.2013.06.013
{Abstract}: <B>BACKGROUND: </B>Traditional white-light endoscopy cannot reliably distinguish between small (<10 mm) adenomatous and hyperplastic colon polyps. High-definition white-light (HDWL) endoscopy and i-Scan may improve in vivo characterization of small colon polyps.<BR><B>OBJECTIVE: </B>To compare HDWL endoscopy and HDWL plus i-Scan for the assessment of small colon polyps and to measure performance against the American Society for Gastrointestinal Endoscopy (ASGE) thresholds for assessment of diminutive colon polyps.<BR><B>METHODS: </B>Prospective cohort study.<BR><B>METHODS: </B>Single academic hospital.<BR><B>METHODS: </B>Patients undergoing bowel cancer screening colonoscopy.<BR><B>METHODS: </B>In vivo assessment of all polyps <10 mm by using HDWL and i-Scan image enhancement.<BR><B>METHODS: </B>The primary outcome measure was overall diagnostic accuracy of in vivo assessment of colon polyps <10 mm. Secondary outcome measures were sensitivity and specificity for adenomatous histology, negative predictive value for adenomatous histology of diminutive rectosigmoid polyps, and accuracy of prediction of polyp surveillance intervals.<BR><B>RESULTS: </B>A total of 209 polyps in 84 patients were included. There were no significant differences between HDWL endoscopy and i-Scan in characterization of polyps <10 mm (accuracy 93.3% vs 94.7%; P = 1.00; sensitivity 95.5% vs 97.0%; P = .50; specificity 89.3% vs 90.7%; P = 1.00). The negative predictive value for adenomatous histology of diminutive rectosigmoid polyps was 100% with both HDWL endoscopy and i-Scan. U.K. and U.S. polyp surveillance intervals were predicted with 95.2% accuracy with HDWL endoscopy and 97.2% accuracy with i-Scan.<BR><B>CONCLUSIONS: </B>Single-center study.<BR><B>CONCLUSIONS: </B>HDWL endoscopy may be as accurate as HDWL with i-Scan image enhancement for the in vivo characterization of small colon polyps. Both modalities fulfil the ASGE performance thresholds for the assessment of diminutive colon polyps. (<BR><B>BACKGROUND: </B>NCT01761279.).