{Reference Type}: Journal Article
{Title}: Metformin: a case of divide and conquer.
{Author}: Anastasiou D;
{Journal}: Breast Cancer Res
{Volume}: 15
{Issue}: 2
{Year}: Mar 2013 11
{Factor}: 8.408
{DOI}: 10.1186/bcr3387
{Abstract}: Metformin is a widely prescribed anti-diabetic drug and its use is associated with lower cancer incidence. The mechanisms by which metformin attenuates tumorigenesis are not clearly understood. In a paper published in Proceedings of the National Academy of Sciences of the United States of America, Hirsch and colleagues show that metformin interferes with a signaling pathway, mediated by the transcription factor NF-κB, which drives cell transformation and is required for the maintenance of cancer stem cells.