{Reference Type}: Journal Article
{Title}: Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: Report of a new case and review of the literature.
{Author}: Otero L;de Souza DC;de Cássia Tavares R;Gomes BE;Padilha TF;Bouzas LF;de Souza Fernandez T;Abdelhay E;
{Journal}: Genet Mol Biol
{Volume}: 35
{Issue}: 4
{Year}: Dec 2012
{Factor}: 2.087
{DOI}: 10.1590/S1415-47572012005000056
{Abstract}: Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient's bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells.