{Reference Type}: Journal Article
{Title}: Anatomic hepatectomy as a definitive treatment for hepatolithiasis: a cohort study.
{Author}: Jarufe N;Figueroa E;Muñoz C;Moisan F;Varas J;Valbuena JR;Bambs C;Martínez J;Pimentel F;
{Journal}: HPB (Oxford)
{Volume}: 14
{Issue}: 9
{Year}: Sep 2012
{Factor}: 3.842
{DOI}: 10.1111/j.1477-2574.2012.00488.x
{Abstract}: <B>BACKGROUND: </B>Treatment requirements in hepatolithiasis may vary and may involve a multidisciplinary approach. Surgical resection has been proposed as a definitive treatment.<BR><B>OBJECTIVE: </B>This study aimed to evaluate the clinical results of anatomic liver resection among Chilean patients with hepatolithiasis.<BR><B>METHODS: </B>An historical cohort study was conducted. Patients who underwent hepatectomy as a definitive treatment for hepatolithiasis from January 1990 to December 2010 were included. Patients with a preoperative diagnosis of cholangiocarcinoma were excluded. Preoperative, operative and postoperative variables were evaluated.<BR><B>RESULTS: </B>A total of 52 patients underwent hepatectomy for hepatolithiasis. The mean ± standard deviation patient age was 49.8 ± 11.8 years (range: 24-78 years); 65.4% of study subjects were female. A total of 75.0% of subjects had a history of previous cholecystectomy. The main presenting symptom was abdominal pain (82.7%). Hepatic involvement was noted in the left lobe in 57.7%, the right lobe in 34.6% and bilaterally in 7.7% of subjects. The rate of postoperative clearance of the biliary tree was 90.4%. Postoperative morbidity was 30.8% and there were no postoperative deaths. Three patients had recurrence of hepatolithiasis, which was associated with Caroli's disease in two of them. Overall 5-year survival was 94.5%.<BR><B>CONCLUSIONS: </B>Anatomic liver resection is an effective treatment in selected patients with hepatolithiasis and is associated with low morbidity and no mortality. At longterm follow-up, anatomic hepatectomy in these patients was associated with a lower rate of recurrence.