{Reference Type}: Journal Article
{Title}: National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach.
{Author}: Montine TJ;Phelps CH;Beach TG;Bigio EH;Cairns NJ;Dickson DW;Duyckaerts C;Frosch MP;Masliah E;Mirra SS;Nelson PT;Schneider JA;Thal DR;Trojanowski JQ;Vinters HV;Hyman BT; ; ;
{Journal}: Acta Neuropathol
{Volume}: 123
{Issue}: 1
{Year}: Jan 2012
{Factor}: 15.887
{DOI}: 10.1007/s00401-011-0910-3
{Abstract}: We present a practical guide for the implementation of recently revised National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease (AD). Major revisions from previous consensus criteria are: (1) recognition that AD neuropathologic changes may occur in the apparent absence of cognitive impairment, (2) an "ABC" score for AD neuropathologic change that incorporates histopathologic assessments of amyloid β deposits (A), staging of neurofibrillary tangles (B), and scoring of neuritic plaques (C), and (3) more detailed approaches for assessing commonly co-morbid conditions such as Lewy body disease, vascular brain injury, hippocampal sclerosis, and TAR DNA binding protein (TDP)-43 immunoreactive inclusions. Recommendations also are made for the minimum sampling of brain, preferred staining methods with acceptable alternatives, reporting of results, and clinico-pathologic correlations.