{Reference Type}: Journal Article
{Title}: A study of association between expression of hOGG1, VDAC1, HK-2 and cervical carcinoma.
{Author}: Guo-Qing P;Yuan Y;Cai-Gao Z;Hongling Y;Gonghua H;Yan T;
{Journal}: J Exp Clin Cancer Res
{Volume}: 29
{Issue}: 0
{Year}: Sep 2010 17
暂无{DOI}: 10.1186/1756-9966-29-129
{Abstract}: <B>BACKGROUND: </B>Human 8-oguanine glycosylase 1(hOGG1), voltage-dependent anion channel 1(VDAC1), hexokinase 2(HK-2), represented the process of oxidative DNA damage, cell apoptosis and glycolysis, respectively. This study aims to explore the association between expression of hOGG1, VDAC1, HK-2 and cervical carcinoma.<BR><B>METHODS: </B>A case-control study was conducted. 65 cervical biopsy samples consist of 20 control and 45 cases. The expression of hOGG1, VDAC1 and HK-2 were examined with immunohistochemistry(IHC), immunolabeling was evaluated with stereological cell counts.<BR><B>RESULTS: </B>The data showed that the positive proportion of hOGG1 and HK-2 in the case group was higher than that of the control group (P < 0.05). Further, there was an increasing trend for the positive proportion and expression degree of hOGG1 and HK-2 from Control, Mild cervical carcinoma (MCC), Intermediate cervical carcinoma(ICC) to Severe cervical carcinoma(SCC) in order (P < 0.05). To VDAC1, the significant result was not obtained.<BR><B>CONCLUSIONS: </B>The results suggested that there was a close association between expression of hOGG1, HK-2 and cervical cancer. hOGG1 and HK-2 might play a key role at the early stage of cervical cancer, and the findings of hOGG1 and HK-2 should be considered as a significant biomarker at the early stage of cervical cancer.