{Reference Type}: Journal Article
{Title}: Guidelines for tunneling in enzymes.
{Author}: Moser CC;Anderson JL;Dutton PL;
{Journal}: Biochim Biophys Acta
{Volume}: 1797
{Issue}: 9
{Year}: Sep 2010
暂无{DOI}: 10.1016/j.bbabio.2010.04.441
{Abstract}: Here we extend the engineering descriptions of simple, single-electron-tunneling chains common in oxidoreductases to quantify sequential oxidation-reduction rates of two-or-more electron cofactors and substrates. We identify when nicotinamides may be vulnerable to radical mediated oxidation-reduction and merge electron-tunneling expressions with the chemical rate expressions of Eyring. The work provides guidelines for the construction of new artificial oxidoreductases inspired by Nature but adopting independent design and redox engineering.