{Reference Type}: Journal Article {Title}: Regulation of information passing by synaptic transmission: a short review. {Author}: Di Maio V; {Journal}: Brain Res {Volume}: 1225 {Issue}: 0 {Year}: Aug 2008 15 {Factor}: 3.61 {DOI}: 10.1016/j.brainres.2008.06.016 {Abstract}: The largest part of information passed among neurons in the brain occurs by the means of chemical synapses connecting the axons of presynaptic neurons to the dendritic tree of the postsynaptic ones. In the present paper, the most relevant open problems related to the mechanisms of control of the information passing among neurons by synaptic transmission will be shortly reviewed. The "cross talking" between synapses, their mutual interactions and the control of the information flow between different areas of the dendritic tree will be also considered. The threshold mechanism based on the "reversal potential" will be considered for its role in the control of information transfer among neurons and also for its contribution to the information flow among different areas of the dendritic tree and to the computational ability of the single neuron. The concept of "competition for plasticity" will be proposed as a mechanism of competition based on the synaptic activation time.