{Reference Type}: Case Reports
{Title}: Trisomy 8 as sole cytogenetic abnormality in a case of chronic lymphocytic leukemia.
{Author}: Lau LC;Kee SK;Tien SL;Koh Mickey BC;
{Journal}: Cancer Genet Cytogenet
{Volume}: 172
{Issue}: 1
{Year}: Jan 2007 1
暂无{DOI}: 10.1016/j.cancergencyto.2006.05.019
{Abstract}: A 49-year-old man, who had been diagnosed with chronic lymphocytic leukemia (CLL) in 2002, had a normal karyotype in his bone marrow. Trisomy 8 was demonstrated in his peripheral blood in 2005. Fluorescence in situ hybridization using an LSI CEP 8 probe performed on the archival bone marrow specimen showed three hybridization signals in 40% of 200 interphase cells scored. This confirmed that the trisomy 8 abnormality was present in both the blood and bone marrow samples. Trisomy 8 as the sole chromosomal abnormality in CLL is a very rare finding. The prognostic significance of trisomy 8 in CLL remains to be seen.