{Reference Type}: Case Reports
{Title}: Mechanism of constipation in familial amyloid polyneuropathy: a case report.
{Author}: Ito T;Sakakibara R;Ito S;Uchiyama T;Liu Z;Yamamoto T;Yamaguchi T;Odaka T;Higashi M;Hattori T;
{Journal}: Intern Med
{Volume}: 45
{Issue}: 20
{Year}: 2006
{Factor}: 1.282
{DOI}: 10.2169/internalmedicine.45.1570
{Abstract}: Previously no functional study has been available for the mechanism of constipation in familial amyloid polyneuropathy (FAP). We performed a gut function test in a 78-year-old woman with transthyretin-type FAP who had severe constipation. The gut function test showed a prolonged colonic transit time, a low anal pressure at rest and upon squeezing, loss of the spontaneous phasic rectal contractions, and weak abdominal strain. All these abnormalities suggested a peripheral autonomic dysfunction, corresponding to the enteric neuropathy that was confirmed upon autopsy.