{Reference Type}: Journal Article
{Title}: Hyperventilation in traumatic brain injury patients: inconsistency between consensus guidelines and clinical practice.
{Author}: Thomas SH;Orf J;Wedel SK;Conn AK;
{Journal}: J Trauma
{Volume}: 52
{Issue}: 1
{Year}: Jan 2002
暂无{DOI}: 10.1097/00005373-200201000-00010
{Abstract}: <B>BACKGROUND: </B>This study assessed patients with traumatic brain injury (TBI) to determine whether prehospital and community hospital providers employed hyperventilation therapy inconsistent with consensus recommendation against its routine use.<BR><B>METHODS: </B>This prospective analysis of 37 intubated TBI patients without herniation, undergoing helicopter transport to an urban Level I center, entailed flight crews' noting of assisted ventilation rate (AVR) and end-tidal carbon dioxide (ETCO2) upon their arrival at trauma scenes or community hospitals. A priori-set levels of AVR and ETCO2 were used to assess frequency of guideline-inconsistent hyperventilation, and Fisher's exact and Kruskal-Wallis tests assessed association between guideline-inconsistent hyperventilation and manual vs. mechanical ventilation mode.<BR><B>RESULTS: </B>Inappropriately high AVR and low ETCO2 were seen in 60% and 70% of patients, respectively. Manual ventilation was associated with guideline-inconsistent hyperventilation assessed by AVR (p = 0.038) and ETCO2 (p = 0.022).<BR><B>CONCLUSIONS: </B>Prehospital and community hospital hyperventilation practices are not consistent with consensus recommendations for limitation of hyperventilation therapy.