{Reference Type}: Case Reports
{Title}: Improvement in cardiac function and free fatty acid metabolism in a case of dilated cardiomyopathy with CD36 deficiency.
{Author}: Hirooka K;Yasumura Y;Ishida Y;Komamura K;Hanatani A;Nakatani S;Yamagishi M;Miyatake K;
{Journal}: Jpn Circ J
{Volume}: 64
{Issue}: 9
{Year}: Sep 2000
暂无{DOI}: 10.1253/jcj.64.731
{Abstract}: A 27-year-old man diagnosed as having dilated cardiomyopathy (DCM) without myocardial accumulation of 123I-beta-methyl-iodophenylpentadecanoic acid, and he was found to have type I CD36 deficiency. This abnormality of cardiac free fatty acid metabolism was also confirmed by other methods: 18F-fluoro-2-deoxyglucose positron emission tomography, measurements of myocardial respiratory quotient and cardiac fatty acid uptake. Although the type I CD36 deficiency was reconfirmed after 3 months, the abnormal free fatty acid metabolism improved after carvedilol therapy and was accompanied by improved cardiac function. Apart from a cause-and-effect relationship, carvedilol can improve cardiac function and increase free fatty acid metabolism in patients with both DCM and CD36 deficiency.