%0 Journal Article
%T Is terbinafine an effective treatment for feline sporotrichosis?
%A Viana PG
%A Gremião IDF
%A da Silva Antonio IM
%A Figueiredo ABF
%A Correa ML
%A Boechat JS
%A de Sá Machado AC
%A de Oliveira RVC
%A Oliveira MME
%A Almeida-Paes R
%A Pereira-Oliveira GR
%A Pereira SA
%J Vet Rec
%V 195
%N 4
%D 2024 Aug 17
%M 39148234
%F 2.56
%R 10.1002/vetr.4435
%X <B>BACKGROUND: </B>Terbinafine has been successfully used in the treatment of human sporotrichosis; however, its effectiveness in the treatment of feline sporotrichosis is unknown. Therefore, this study aimed to describe the use of terbinafine in the treatment of feline sporotrichosis.<BR><B>METHODS: </B>A cohort study was conducted in cats with sporotrichosis to assess the effectiveness and safety of terbinafine (30‒60 mg/kg/day). Clinical examination and analysis of laboratory parameters were performed monthly until clinical signs resolved or terbinafine treatment was discontinued.<BR><B>RESULTS: </B>Of the 54 cats with sporotrichosis included in the study, 19 were lost during follow-up and five were withdrawn from the study due to switching to treatment with another prescription drug. Of the remaining 30 cats, 10 achieved clinical cure, with a median treatment time of 18.5 weeks. Treatment failed in 18 cases, and two cats died. Twenty-two cats had adverse reactions to terbinafine treatment, and 10 cats showed elevation of serum transaminases.<BR><B>CONCLUSIONS: </B>Loss during follow-up was high, which makes it difficult to draw accurate conclusions regarding clinical outcomes.<BR><B>CONCLUSIONS: </B>The low rate of clinical cure observed suggests that terbinafine does not represent an effective treatment option for cases of feline sporotrichosis.