%0 Journal Article
%T Clinical Predictors of Nontuberculous Mycobacteria Lung Disease and Coisolates of Potential Pathogenic Microorganisms in Noncystic Fibrosis Bronchiectasis.
%A Wang PH
%A Shu CC
%A Sheu CC
%A Chang CL
%A Hsieh MH
%A Hsu WH
%A Chen MT
%A Ou WF
%A Wei YF
%A Yang TM
%A Lan CC
%A Wang CY
%A Lin CB
%A Lin MS
%A Wang YT
%A Lin CH
%A Liu SF
%A Cheng MH
%A Chen YF
%A Cheng WC
%A Peng CK
%A Chan MC
%A Chen CY
%A Jao LY
%A Wang YH
%A Chen CJ
%A Chen SP
%A Tsai YH
%A Cheng SL
%A Lin HC
%A Chien JY
%A Wang HC
%J Open Forum Infect Dis
%V 11
%N 8
%D 2024 Aug
%M 39145140
%F 4.423
%R 10.1093/ofid/ofae427
%X <B>UNASSIGNED: </B>In bronchiectasis, nontuberculous mycobacteria (NTM) lung disease (NTM-LD) is a well-known coexisting infection. However, microorganism coisolates and clinical NTM-LD predictors are poorly studied.<BR><B>UNASSIGNED: </B>Patients with bronchiectasis diagnosed by means of computed tomography between January 2017 and June 2020 were screened, using the date of computed tomography as the index date. Those with a major bronchiectasis diagnosis in ≥2 follow-up visits after the index date were enrolled in the study, and NTM-LD occurrence and its association with pneumonia and hospitalization within 1 year were analyzed.<BR><B>UNASSIGNED: </B>Of the 2717 participants, 79 (2.9%) had NTM-LD diagnosed. The factors associated with NTM-LD included hemoptysis, postinfectious bronchiectasis, a tree-in-bud score ≥2, a modified Reiff score ≥4, and chronic obstructive pulmonary disease (adjusted odds ratios, 1.80, 2.36, 1.78, 2.95, and 0.51, respectively). Compared with patients in the non-NTM group, those with NTM-LD had higher rates of hospitalization (15.9% vs 32.9%; P < .001) and pneumonia (9.8% vs 20.3%; P = .003). Pseudomonas aeruginosa was the most common microorganism in those with NTM-LD and those in the non-NTM group (10.1% vs 7.8%; P = .40). However, compared with those in the non-NTM group, Acinetobacter baumannii and Escherichia coli were more prevalent in patients with NTM-LD (0.7% vs 3.8% [P = .03%] and 1.0% vs 3.8% [P = .05], respectively).<BR><B>UNASSIGNED: </B>Postinfectious bronchiectasis with hemoptysis, higher radiological involvement, and a tree-in-bud pattern were associated with NTM-LD risk. The rate of A baumannii and E coli coisolation was higher in bronchiectasis populations with NTM-LD.