%0 Journal Article %T Long survivors after radical cystectomy versus healthy population: propensity score matched analysis of health-related quality of life. %A Mastroianni R %A Iannuzzi A %A Ragusa A %A Flammia RS %A Tuderti G %A Anceschi U %A Bove AM %A Brassetti A %A D'Annunzio S %A Ferriero M %A Misuraca L %A Proietti F %A Anselmi M %A Guaglianone S %A Leonardo C %A Papalia R %A Simone G %J World J Urol %V 42 %N 1 %D 2024 Aug 14 %M 39143260 %F 3.661 %R 10.1007/s00345-024-05187-8 %X OBJECTIVE: To investigate Health Related Quality of Life (HRQoL) features of long survivors after radical cystectomy (RC) compared to healthy population (HP) control.
METHODS: Patients with cT2-4/N0/M0 or Bacillus Calmette-Guérine (BCG) failure high-grade non-muscle-invasive bladder cancer (NMIBC) undergoing RC and ileal Orthotopic Neobladder (iON) from 2010 to 2015 were enrolled in "BCa cohort". Patients aged ≥ 18 yrs old, with no previous diagnosis of BCa or any genitourinary cancer disease were included from General Practitioner outpatients and enrolled in "HP cohort". A 1:1 propensity score matched (PSM) analysis was performed, and HRQoL outcomes were collected according to European Organization for Research and Treatment of Cancer (EORTC), and generic (QLQ-C30) questionnaires.
RESULTS: A total of 401 patients were enrolled in the study, 99 and 302 in BCa and HP cohorts, respectively. After applying 1:1 PSM analysis 67 patients were included for each group. Analysis of self-reported HRQoL outcomes described a better HRQoL in BCa cohort. Particularly, in the long run patients receiving RC and iON significantly experienced higher global health-status/QoL (p < 0.001), emotional (p = 0.003) and cognitive functioning (p < 0.001) than HP cohort, providing a significantly lower impairment in terms of fatigue (p = 0.004), pain (p = 0.004), dyspnea (p = 0.02) and insomnia (p = 0.005).
CONCLUSIONS: Long survivors after RC and iON seems to have a major awareness of self-reported HRQoL compared to HP control group.