%0 Journal Article
%T Usefulness of pre- and post-treatment volumetric PET/CT parameters in predicting prognosis and evaluating recurrence for chemoradiotherapy-treated hypopharyngeal cancer.
%A Okazaki E
%A Koyama K
%A Higashikawa M
%A Nishida N
%A Fukuda H
%J Eur Arch Otorhinolaryngol
%V 0
%N 0
%D 2024 Aug 14
%M 39141132
%F 3.236
%R 10.1007/s00405-024-08905-5
%X <B>OBJECTIVE: </B>To investigate the usefulness of pre- and post-treatment metabolic tumor volume (MTV) obtained from positron emission tomography (PET) in predicting prognosis and evaluating recurrence in patients with hypopharyngeal cancer (HPC).<BR><B>METHODS: </B>Forty-three consecutive HPC patients treated with chemoradiotherapy were retrospectively analyzed. Maximum standard uptake value (SUVmax) and MTV of tumor (T) and lymph node (N) were analyzed.<BR><B>RESULTS: </B>On multivariate analysis using pre-treatment parameters, MTV-T (p = 0.049) and MTV-TN (p = 0.043) were significantly associated with local control (LC), and MTV-N (p = 0.049) was significantly associated with disease-specific survival (DSS). Post-treatment MTV-TN was also significantly associated with prognosis (p < 0.001 in LC; p = 0.002 in DSS) and recurrence (area under curve 0.95). Neither pre- nor post-treatment SUVmax was significantly associated with prognosis.<BR><B>CONCLUSIONS: </B>Pre- and post-treatment MTV appears useful for predicting prognosis and evaluating recurrence.