%0 Journal Article
%T Inflammation and all-cause mortality in patients undergoing peritoneal dialysis.
%A Oliveira Júnior WV
%A Giarola LTP
%A Ferreira LGR
%A Schettini IVG
%A Turani SD
%A Oliveira AR
%A Marinho MAS
%A Pinto SWL
%A Barros-Pinheiro M
%A Figueiredo RC
%A Rios DRA
%J Einstein (Sao Paulo)
%V 22
%N 0
%D 2024
%M 39140572
暂无%R 10.31744/einstein_journal/2024AO0627
%X <B>OBJECTIVE: </B>This study aimed to evaluate inflammatory biomarkers in patients undergoing peritoneal dialysis and investigate their association with all-cause mortality or transfer to hemodialysis.<BR><B>METHODS: </B>This prospective cohort study included 43 patients undergoing peritoneal dialysis. Plasma levels of cytokines were measured using flow cytometry and capture enzyme-linked immunosorbent assay. Biomarkers were categorized based on their respective median values. Survival analysis was conducted using the Kaplan-Meier estimator, considering two outcomes: all-cause mortality and transfer to hemodialysis.<BR><B>RESULTS: </B>After adjusting for confounding factors, plasma levels above the median of the levels of CCL2 and plasma, as well as below the median of TNF-α, and the median of dialysate IL-17 levels, were associated with an increased risk of experiencing the specified outcomes after approximately 16 months of follow-up.<BR><B>CONCLUSIONS: </B>These findings suggest that inflammatory biomarkers may be a valuable tool for predicting all-cause mortality and transfer to hemodialysis in patients undergoing peritoneal dialysis.