%0 Journal Article
%T Safety and efficacy of very low calorie diet in patients receiving haemodialysis therapy.
%A Woods JE
%A Snelson A
%A Kok J
%A Leger MA
%A Wei J
%A Hung J
%A Rio R
%A Medara S
%A Prasad S
%A Ganesh K
%A Kerr PG
%A Polkinghorne KR
%J Clin Kidney J
%V 17
%N 8
%D 2024 Aug
%M 39139183
%F 5.86
%R 10.1093/ckj/sfae217
%X <B>UNASSIGNED: </B>Very low calorie diets (VLCDs) are an obesity treatment option in the general population, but their efficacy and safety in patients on haemodialysis (HD) is unknown.<BR><B>UNASSIGNED: </B>Prospective single arm study of VLCD in haemodialysis patients. All participants received 2.5-3.3 MJ/day for 12 weeks. Weekly assessment of VLCD, pre- and post-dialysis weight, inter-dialytic weight gain, and blood electrolytes occurred for the first 4 weeks, then fortnightly for another 8 weeks. Linear mixed models compared the change in weight over time as well as biochemical outcomes including potassium.<BR><B>UNASSIGNED: </B>Twenty-two participants [nine home HD (HHD) and 13 satellite HD (SHD)] enrolled with 19 completing the 12-week intervention. Mean post-dialysis weight declined from 121.1 kg at baseline to 109.9 at week 12 resulting in average decline of 0.88 kg per week (95% C.I. 0.71, 1.05, P < .001) with 12-week mean percentage weight loss9.3% (SD 3.5). Mean post-dialysis body mass index declined from 40.9 kg/m2 at baseline to 37.1 kg/m2 at week 12 (95% C.I. 0.25, 0.35, P < .001). Serum potassium rose from week 1 to 3, stabilized during weeks 4 to 6, and fell from week 8, returning near baseline by week 12. Six of the nine (66.6%) HHD participants and seven of the 13 (70%) SHD participants had at least one episode of hyperkalaemia (K > 6 mmol/l). There were no clinical changes in serum sodium, corrected calcium, or phosphate levels during the study.<BR><B>UNASSIGNED: </B>VLCD with dietitian supervision was effective in producing significant weight reduction, with an acceptable safety profile in patients treated with haemodialysis.