%0 Journal Article
%T Long-term association between water intake and kidney function in a population at high cardiovascular risk.
%A Paz-Graniel I
%A Valle-Hita C
%A Babio N
%A Serra-Majem L
%A Vioque J
%A Zomeño MD
%A Corella D
%A Pintó X
%A Cano-Ibáñez N
%A Tur JA
%A Cuadrado-Soto E
%A Martínez JA
%A Díaz-López A
%A Torres-Collado L
%A Goday A
%A Fernández-Carrión R
%A Nissenshon M
%A Riera-Mestre A
%A Garrido-Garrido E
%A Bouzas C
%A Abete I
%A Daimiel L
%A Cornejo-Pareja I
%A Vázquez-Ruiz Z
%A Khoury N
%A Pérez-Vega KA
%A Salas-Salvadó J
%J J Nutr Health Aging
%V 28
%N 9
%D 2024 Aug 12
%M 39137622
%F 5.285
%R 10.1016/j.jnha.2024.100327
%X <B>OBJECTIVE: </B>The evidence on water intake in the prevention of kidney function decline is scarce at population level in well-being individuals at high cardiovascular risk. Therefore, we aimed to longitudinally evaluate the associations between total water intake and subtypes and kidney function, through estimated-Glomerular Filtration Rate (eGFR).<BR><B>METHODS: </B>Three-year prospective analysis conducted in 1986 older adults (aged 55-75 year) with overweight/obesity and metabolic syndrome from the PREDIMED-Plus study. Water intake was assessed using validated beverage and food frequency questionnaires. Serum creatinine-based eGFR (SCr-based eGFR; ml/min/1.73 m2) was estimated using the CKD-EPI equation at baseline, one-year and 3-years of follow-up. Mixed-effects linear regression models were fitted to evaluate the associations between baseline total water intake and subtypes, and SCr-based eGFR over 3-years of follow-up.<BR><B>RESULTS: </B>Participants in the highest baseline tertile of total water intake, plain water and water from all fluids showed a lower decrease in SCr-based eGFR after 3-years of follow-up, compared to those in the lowest tertile. Participants with the highest tap water consumption showed a lower SCr-based eGFR decline after 1-year and 3-years of follow-up, in comparerd to participants in the lowest intake category (T3 vs. T1: β: 1.4 ml/min/1.73 m2; 95%CI: 0.5-2.3, β: 1.0; 95%CI: 0.1-2.0, respectively).<BR><B>CONCLUSIONS: </B>Plain water rather than other water sources, and especially tap water, was associated with lower kidney function decline assessed through eGFR over 3-years of follow-up, in older individuals at high cardiovascular risk.<BR><B>BACKGROUND: </B>ISRCTN89898870. Retrospectively registered on 24 July 2014.