%0 Journal Article
%T Prevalence of Metabolic Dysfunction-associated Steatotic Liver Disease and Cardiometabolic Risk Factor in US Adolescents.
%A Zheng X
%A Zhao D
%A Wang L
%A Wang Y
%A Chen Y
%A Zhang Y
%J J Clin Endocrinol Metab
%V 0
%N 0
%D 2024 Aug 13
%M 39136243
%F 6.134
%R 10.1210/clinem/dgae553
%X <B>BACKGROUND: </B>Metabolic dysfunction-associated steatotic liver disease (MASLD) is widespread worldwide, and a strong link between MASLD and cardiometabolic risk factors (CMRFs) was emphasized.<BR><B>OBJECTIVE: </B>This study characterized the prevalence of MASLD in adolescent population and overlapping CMRFs conditions in MASLD.<BR><B>METHODS: </B>This is a cross-sectional study of US adolescents aged 12--19 years in the 2017-2020 cycles of the National Health and Nutrition Examination Survey. The relationship between CMRFs and liver steatosis, evaluated by the median controlled attenuation parameter (CAP), was assessed.<BR><B>RESULTS: </B>The prevalence of MASLD in adolescents was 23.77%. Isolated overweight/obesity (35%) was the top CMRF. Non-Hispanic Black patients had the highest proportion of overweight/obesity plus elevated glucose (24%), while non-Hispanic Asian had the highest burden of dyslipidemia (2%, 14%, and 19%). Except hypertension, overweight/obesity (β=48.7; 95% CI, 43.4-54.0), hypertriglyceridemia (β=15.5; 95% CI, 7.2-28.3), low HDL-C (β=10.0; 95% CI, 3.1-16.9), elevated glucose (β=6.9; 95% CI, 0.6-13.2) were all significantly associated with increased CAP values. Increased CAP was linked to the synergistic interactions between overweight/obesity and dyslipidemia or elevated glucose (overweight/obesity and elevated glucose: RERI=8.21, AP=0.45, SI=1.91; overweight/obesity and hypertriglyceridemia: RERI=19.00, AP=0.69, SI=3.53; overweight/obesity and low HDL-C: RERI=10.83, AP=0.58, SI=2.61). Adolescents with combination of overweight/obesity, dyslipidemia (β=15.1; 95% CI, 0.1-30.2) and combination of overweight/obesity, dyslipidemia and elevated glucose (β=48.0; 95% CI, 23.3-72.6) had a significantly higher CAP values.<BR><B>CONCLUSIONS: </B>The prevalence of MASLD was alarmingly high in adolescents, and overweight/obesity was the most important CMRF. Overweight/obesity and dyslipidemia or elevated glucose had positive additive interaction effects on liver steatosis.