%0 Journal Article
%T Multisociety research collaboration: timing of cholecystectomy following cholecystostomy drainage for acute cholecystitis.
%A Spaniolas K
%A Pryor A
%A Stefanidis D
%A Giannopoulos S
%A Miller PR
%A Spencer AL
%A Docimo S
%A DuCoin C
%A Ross SW
%A Schiffern L
%A Reinke C
%A Sherrill W
%A Nahmias J
%A Manasa M
%A Kindel T
%A Wijekulasooriyage D
%A Cardinali L
%A Di Saverio S
%A Yang J
%A Liao Y
%J Surg Endosc
%V 0
%N 0
%D 2024 Aug 12
%M 39134720
%F 3.453
%R 10.1007/s00464-024-11145-7
%X <B>BACKGROUND: </B>Patients with acute cholecystitis (AC) presenting with unfavorable systemic or local conditions are often managed with percutaneous cholecystostomy (PC) as a temporary measure. The clinical outcomes of interval cholecystectomy following PC remain unclear. The aim of the study was to identify the association between the timing of cholecystectomy following PC for AC and perioperative complication rates at interval cholecystectomy. We hypothesized that there would be a specific time interval to cholecystectomy associated with lower risk for adverse events.<BR><B>METHODS: </B>This was a retrospective (2018-2020) multicenter study at 8 participating hospital systems of adult patients with AC, managed with PC and interval cholecystectomy. Demographics, comorbidities, treatment details, and outcomes were examined. Patients were grouped based on quartiles for timing of surgery after PC (< 7, 7-9, 10-13, > 13 weeks). The primary outcome was a composite endpoint of bile duct injury, reoperation, readmission, image-guided intervention, endoscopic intervention, conversion to open surgery, or death.<BR><B>RESULTS: </B>There were 188 patients with a median age of 66 years with AC classified as mild (41%), moderate (47%), and severe (12%). Median days from PC to surgery were 65 (Q1 = 48, Q3 = 91). Laparoscopic cholecystectomy (89.9%) was the most commonly planned approach (robotic 6.4%, 3.7% open) and 28 (14.9%) were converted to open. The composite endpoint was reported in 51 patients (27.1%). A biliary injury occurred in 7 (3.7%) patients. Time to surgery and intraoperative drain placement were independently associated with the composite outcome. Cholecystectomy within 7 weeks of PC was associated with decreased risk (OR = 0.36, 95% CI 0.13-0.97) of the composite endpoint, compared to patients undergoing surgery > 13 weeks after PC.<BR><B>CONCLUSIONS: </B>Timing of surgery following PC was associated with procedural outcomes. Patients undergoing surgery before 7 weeks experienced significantly less morbidity than patients having delayed cholecystectomy. These results should be considered in patient selection and management after PC.