%0 Journal Article
%T Therapeutic Potential of Blocking Nephrin Phosphorylation to Improve Pancreatic β-cell Function.
%A Joseph JW
%J Endocrinology
%V 165
%N 10
%D 2024 Aug 27
%M 39133576
%F 5.051
%R 10.1210/endocr/bqae104
%X The phosphorylation of the transmembrane protein nephrin has been shown to play an important role in signaling in kidney podocytes, and it has now been shown to also play a key role in regulating pancreatic β-cell function. Williamson et al have recently shown that the loss of nephrin tyrosine phosphorylation on its 3 cytoplasmic YDxV motifs can enhance insulin release in aged female mice. These studies suggest that blocking nephrin phosphorylation may be an effective treatment option for improving β-cell function.