%0 Journal Article
%T Outcomes of the Novel Supreme Drug-Eluting Stent in Complex Coronary Lesions: A PIONEER III Substudy.
%A Patel KP
%A Lansky AJ
%A Kereiakes DJ
%A Windecker S
%A Cristea E
%A Pietras C
%A Dressler O
%A Issever MO
%A Curtis M
%A Bertolet B
%A Zidar JP
%A Smits PC
%A Jiménez Díaz VA
%A McLaurin B
%A Brogno DA
%A Janssens L
%A Vrolix MC
%A Gómez-Blázquez I
%A Sahul ZH
%A Kabour A
%A Salido L
%A Cleman M
%A Saito S
%A Leon MB
%A Baumbach A
%A  
%J J Soc Cardiovasc Angiogr Interv
%V 1
%N 1
%D 2022 Jan-Feb
%M 39130138
暂无%R 10.1016/j.jscai.2021.100004
%X <B>UNASSIGNED: </B>The Supreme healing-targeted drug-eluting stent (DES) is designed to promote endothelial healing to reduce stent-related adverse events. This may be particularly relevant among complex lesions that have a higher rate of adverse events. We sought to compare 1-year outcomes of percutaneous coronary intervention in complex lesions between the Supreme DES and contemporary durable-polymer, everolimus-eluting stents (DP-EES).<BR><B>UNASSIGNED: </B>PIONEER III was a multicenter, prospective, single-blind clinical trial, randomizing 1629 patients with either an acute or chronic coronary syndrome in a 2:1 ratio to the Supreme DES or DP-EES. Complex lesions (American College of Cardiology/American Heart Association type B2/C) were found in 1137 patients. Outcomes were also compared for specific parameters of lesion complexity: severe calcification, long length (>20 ​mm), and severe tortuosity. The primary end point was target lesion failure at 1 ​year.<BR><B>UNASSIGNED: </B>At 1 ​year, there was no difference in target lesion failure between the Supreme DES and DP-EES: (5.7% vs 5.6%; hazard ratio 1.00, 95% confidence interval 0.59-1.68, P = .99). Similarly, there were no differences in the secondary end points of lesion success (99.7% vs 99.4%, P = .41), device success (97.0% vs 98.5%, P = .14), target vessel failure (6.5% vs 7.4%, P = .50), major adverse cardiac events (7.8% vs 8.5%, P = .64), or stent thrombosis (0.7% vs 1.1%, P = .48). A trend was observed toward a higher rate of target lesion revascularization with the Supreme DES (2.5% vs 0.9%, P = .06).<BR><B>UNASSIGNED: </B>This study suggests that the Supreme DES is as effective and safe at 1 ​year compared with the standard DP-EES across a broad spectrum of lesion complexity.