%0 Journal Article
%T Genetic Features of Tongue Cancer Recurrence in Young Adults.
%A Kolegova ES
%A Schegoleva AA
%A Vorobev RS
%A Fedorova IK
%A Kulbakin DE
%A Polyakov AP
%A Mordovsky AV
%A Yakovleva LP
%A Vyalov AS
%A Tsiklauri VT
%A Kropotov MA
%A Suchkova NG
%A Sukortseva NS
%A Reshetov IV
%A Choinzonov EL
%A Denisov EV
%J Bull Exp Biol Med
%V 177
%N 3
%D 2024 Jul 11
%M 39127975
%F 0.737
%R 10.1007/s10517-024-06189-7
%X To identify genetic alterations associated with tongue cancer recurrence in young adults, whole exome sequencing of the primary tumor, recurrence, and whole blood samples from young patients with tongue cancer was performed. A frameshift mutation in the TP53 gene was detected in the primary tumor and recurrence tumor tissue. A mutation in the EPHB6 gene was detected in the recurrence and was absent in the primary tumor. In addition, the primary tumor and recurrence tongue cancer tissue harbored amplification of the 20p13 region containing C20orf96, DEFB125, DEFB126, DEFB127, DEFB128, DEFB129, DEFB132, and ZCCHC3 genes. Thus, genetic alterations have been identified that are associated with tongue cancer recurrence in young adults.