%0 Journal Article
%T Cost-effective endoscopic screening for gastric cancer in a cohort with low Helicobacter pylori prevalence.
%A Ishibashi F
%A Suzuki S
%A Kobayashi K
%A Tanaka R
%A Kawakami T
%A Mochida K
%A Nagai M
%A Ishibashi Y
%A Morishita T
%J J Gastroenterol Hepatol
%V 0
%N 0
%D 2024 Aug 9
%M 39126193
%F 4.369
%R 10.1111/jgh.16715
%X <B>OBJECTIVE: </B>Periodic endoscopic screening for gastric cancer (GC) is widely performed in East Asia; however, the optimal screening strategy remains unclear. This study aimed to determine the most cost-effective endoscopic screening strategy for the detection and treatment of GC in a cohort with a low Helicobacter pylori prevalence.<BR><B>METHODS: </B>The following data were retrospectively extracted from participants who received screening endoscopy between April 2019 and March 2023: age, H. pylori infection status, presence of intestinal metaplasia, pathological diagnosis of GC, and the interval between the most recent endoscopies. A Markov state transition model was constructed based on the cohort data. The cost-effectiveness of 15 strategies with different starting ages (40/50/60 years) and screening intervals (1/2/3/4/5 years) was compared. The net monetary benefit (NMB) and incremental cost-effectiveness ratio (ICER) of quality-adjusted life-years gained by treatment were used as outcomes.<BR><B>RESULTS: </B>A simulation model was constructed based on the cohort data of 94 137 participants (mean age 54.5 years, males 57.9%; 74.4% H. pylori-naïve, 94.2% intestinal metaplasia-negative). The results of the base-case analysis showed that the screening strategy of 4-year intervals starting at the age of 40 years had the highest NMB (97 401 578 yen). In both the Monte Carlo simulation and one-way sensitivity analysis with a varying probability of H. pylori infection status transition, the ICER was superior in the screening strategy every 4 years, starting at age 40 years.<BR><B>CONCLUSIONS: </B>Our simulation showed that endoscopic screening at 4-year intervals starting at the age of 40 years was the most cost-effective method.