%0 Journal Article
%T Prying the lid open: Atomic-level insights on sialoglycan-TMPRSS2 coordination in HKU1 entry.
%A Parsons RJ
%A Acharya P
%J Cell
%V 187
%N 16
%D 2024 Aug 8
%M 39121845
%F 66.85
%R 10.1016/j.cell.2024.07.007
%X The pre-fusion coronavirus HKU1 spike binds host sialoglycans and proteinaceous receptor TMPRSS2 for cell entry. In this issue of Cell, three papers by Fernández et al., McCallum et al., and Wang et al. provide structural information on HKU1 spike interactions with host receptors, providing insights into its multi-step opening.