%0 Journal Article %T Decoding the end of message: PASTA provides food for thought on mechanisms of alternative polyadenylation. %A Tian B %J Mol Cell %V 84 %N 15 %D 2024 Aug 8 %M 39121842 %F 19.328 %R 10.1016/j.molcel.2024.07.015 %X In a recent publication in Cell, Kowalski et al.1 developed an interdisciplinary and multiplexed approach to uncover regulatory modules of alternative polyadenylation, involving single-cell-based gene perturbation, isoform abundance analysis, machine learning of RNA motifs, and massively parallel reporter assays.