%0 Journal Article
%T A rare association of pheochromocytoma, paraganglioma, and pituitary adenoma (3PA): A case report and literature review.
%A Rahmati R
%A Meftah E
%A Hamidi H
%A Esfahanian F
%J Medicine (Baltimore)
%V 103
%N 32
%D 2024 Aug 9
%M 39121253
%F 1.817
%R 10.1097/MD.0000000000038928
%X <B>BACKGROUND: </B>3P association (3PA) is a rare condition with co-occurrence of pituitary adenoma and pheochromocytoma/paraganglioma. There have been less than a hundred documented cases of 3PA, which can be sporadic or related to genetic mutations. The present case report describes the first Iranian patient with 3PA and a 90th case of 3PA in the available literature.<BR><B>UNASSIGNED: </B>A 36-year-old Caucasian male was admitted with headache and sudden increase in blood pressure. An abdominal CT scan revealed a retroperitoneal mass posterior to the inferior vena cava, later removed and diagnosed as a pheochromocytoma. Four years later, he noticed occasional mild headaches and a painless mass on the right side of his neck. The ultrasonography evaluations suggested a carotid body tumor, which was surgically removed. About a month after his second surgery, the severity of the patient's headaches worsened, and he developed right homonymous hemianopia. A brain MRI showed a mass in favor of macroadenoma, craniopharyngioma, or meningioma, and elevated prolactin level led to the diagnosis of macroprolactinoma.<BR><B>METHODS: </B>Based on the provided history, this patient was diagnosed with 3PA, and a genetic study identified a positive succinate-dehydrogenase-complex subunit b mutation, possibly linked to his family history of carotid body tumor.<BR><B>RESULTS: </B>He has remained symptom-free during his visits every 3 months.<BR><B>CONCLUSIONS: </B>The number of cases diagnosed with 3PA worldwide is increasing. Using clinical and genetic assessments, we can timely diagnose and adequately monitor individuals with or at risk of 3PA.