%0 Journal Article
%T Hallmarks of perineural invasion in pancreatic ductal adenocarcinoma: new biological dimensions.
%A Sun Y
%A Jiang W
%A Liao X
%A Wang D
%J Front Oncol
%V 14
%N 0
%D 2024
%M 39119085
%F 5.738
%R 10.3389/fonc.2024.1421067
%X Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant tumor with a high metastatic potential. Perineural invasion (PNI) occurs in the early stages of PDAC with a high incidence rate and is directly associated with a poor prognosis. It involves close interaction among PDAC cells, nerves and the tumor microenvironment. In this review, we detailed discuss PNI-related pain, six specific steps of PNI, and treatment of PDAC with PNI and emphasize the importance of novel technologies for further investigation.