%0 Journal Article
%T The relationship between sex hormone levels and ocular surface parameters in girls with idiopathic central precocious puberty.
%A Jiang W
%A Yang L
%A Liang S
%J Front Endocrinol (Lausanne)
%V 15
%N 0
%D 2024
%M 39119007
%F 6.055
%R 10.3389/fendo.2024.1429154
%X <B>UNASSIGNED: </B>The study aimed to investigate the correlation between the change of sex hormone levels and ocular surface parameters in girls with idiopathic central precocious puberty(ICPP).<BR><B>UNASSIGNED: </B>Eighteen girls with ICPP and 18 age-matched normal girls participated in this study, all of the participants had undergone physical measurements, laboratory tests, imaging examination and ocular surface assessments.<BR><B>UNASSIGNED: </B>The Objective Scatter Index (OSI) in the ICPP group was significantly higher than in the control group (P = 0.031), girls with ICPP showed slightly lower MNITBUT compared to the normal control group, although this difference was not statistically significant. Bivariate analysis revealed a positive association between estradiol and OSI (r=0.383, P=0.021), Additionally, in the study population, both Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH) were negatively correlated with Mean noninvasive tear breakup time (MNITBUT) (r=-0.359, P=0.031)(r=-0.357, P=0.032).<BR><B>UNASSIGNED: </B>In comparison with the normal control group, alterations in the OSI were observed in girls with ICPP. This alteration may be associated with an elevation in estrogen levels. Although there was a slight non-significant decrease in NITBUT in ICPP girls, the negative correlation between LH and FSH with MNITBUT suggests new perspective for further investigation.