%0 Journal Article
%T Characterizing microstructural patterns within the cortico-striato-thalamo-cortical circuit in Parkinson's disease.
%A Shang S
%A Wang L
%A Yao J
%A Lv X
%A Xu Y
%A Dou W
%A Zhang H
%A Ye J
%A Chen YC
%J Prog Neuropsychopharmacol Biol Psychiatry
%V 135
%N 0
%D 2024 Aug 6
%M 39116929
%F 5.201
%R 10.1016/j.pnpbp.2024.111116
%X <B>OBJECTIVE: </B>Parkinson's disease (PD) involves pathological alterations that include cortical impairments at levels of region and network. However, its microstructural abnormalities remain to be further elucidated via an appropriate diffusion neuroimaging approach. This study aimed to comprehensively demonstrate the microstructural patterns of PD as mapped by diffusion kurtosis imaging (DKI).<BR><B>METHODS: </B>The microstructure of grey matter in both the PD group and the matched healthy control group was quantified by a DKI metric (mean kurtosis). The intergroup difference and classification performance of global microstructural complexity were analyzed in a voxelwise manner and via a machine learning approach, respectively. The patterns of information flows were explored in terms of structural connectivity, network covariance and modular connectivity.<BR><B>RESULTS: </B>Patients with PD exhibited global microstructural impairments that served as an efficient diagnostic indicator. Disrupted structural connections between the striatum and cortices as well as between the thalamus and cortices were widely distributed in the PD group. Aberrant covariance of the striatocortical circuitry and thalamocortical circuitry was observed in patients with PD, who also showed disrupted modular connectivity within the striatum and thalamus as well as across structures of the cortex, striatum and thalamus.<BR><B>CONCLUSIONS: </B>These findings verified the potential clinical application of DKI for the exploration of microstructural patterns in PD, contributing complementary imaging features that offer a deeper insight into the neurodegenerative process.