%0 Journal Article
%T IgG4-related Disease Concomitant with Diffuse Large B-cell Lymphoma.
%A Yanagisawa H
%A Mishima K
%A Yamanouchi Y
%A Ueda Y
%A Yamano T
%A Iwao-Kawanami H
%A Sakai T
%A Kawanami T
%A Yamada K
%A Kawano M
%A Mizuta S
%A Fukushima T
%A Masaki Y
%J Intern Med
%V 0
%N 0
%D 2024 Aug 8
%M 39111885
%F 1.282
%R 10.2169/internalmedicine.4010-24
%X A 77-year-old man presented with right inguinal lymphadenopathy and swollen parotid and submandibular glands bilaterally. Histopathology revealed germinal center B-cell type diffuse large B-cell lymphoma (DLBCL) in the inguinal lymph node. Lymphocyte and plasma cell infiltration in the submandibular gland with elevated serum IgG4 levels (13 g/L) prompted a diagnosis of IgG4-related disease (IgG4-RD). Systemic chemotherapy for DLBCL led to shrinkage of the lymph nodes and disappearance of the submandibular gland swelling, as confirmed by fluorodeoxyglucose-positron emission tomography/computed tomography. Although concomitant IgG4-RD and lymphoma have been reported, their simultaneous diagnosis is rare; therefore, a biopsy of all involved organs is crucial in cases with unusual organ involvement.