%0 Journal Article
%T Advanced biopolymeric materials and nanosystems for RNA/DNA vaccines: a review.
%A T Pereira LF
%A R Tredus JG
%A Corá LO
%A Novacki LL
%A D Oliveira GE
%A Vodiani M
%A Dias IP
%A V Filho RX
%A Picheth GF
%J Nanomedicine (Lond)
%V 0
%N 0
%D 2024 Aug 7
%M 39110059
%F 6.096
%R 10.1080/17435889.2024.2382077
%X The post COVID-19 pandemic era has emerged with more efficient vaccines, all based on genetic materials. However, to expand the use of nucleic components as vaccines, a new generation of nanosystems particularly constructed to increase RNA/DNA stability, half-life and facilitate administration are still required. This review highlights novel developments in mRNA and pDNA vaccines formulated into nanostructures exclusively composed by biopolymeric materials. Recent advances suggest that a new generation of vaccines may arise by adapting the structural features of biopolymers with the effectiveness of nucleic acids. The advantages offered by biopolymers, such as increased stability and targeting ability may cause a revolution in the immunization field for offering promptly adaptable and effective formulations for worldwide distribution.<BR>[Box: see text].