%0 Journal Article
%T Asymptomatic infection and disappearance of clinical symptoms of COVID-19 infectors in China 2022-2023: a cross-sectional study.
%A Zhang K
%A Zhong X
%A Fan X
%A Yu D
%A Chen Z
%A Zhao C
%A Zhang X
%A Guan Z
%A Wei X
%A Wan S
%A Zhang X
%A Zhao M
%A Dai Q
%A Liu W
%A Xu Q
%A Kong Y
%A Han S
%A Lin H
%A Wang W
%A Jiang H
%A Gu C
%A Zhang X
%A Jiang T
%A Liu S
%A Cui H
%A Yang X
%A Jiang Y
%A Chen Z
%A Sun Y
%A Tao L
%A Zheng R
%A Qiu R
%A You L
%A Shang H
%J Sci Rep
%V 14
%N 1
%D 2024 08 6
%M 39107338
%F 4.996
%R 10.1038/s41598-024-68162-8
%X To explore the clinical characteristics of patients infected with SARS-CoV-2 nationwide, especially the effect factors of asymptomatic infection and disappearance of clinical symptoms. A total of 66,448 COVID-19 patients in China who have been diagnosed by nucleic acid test or rapid antigen test were surveyed online (December 24, 2022 to January 16, 2023). Our cross-sectional study used descriptive analyses and binary Logistics regression model to assess the correlation between the clinical characteristics and relative factors, including age, gender, pre-existing conditions, reinfection, vaccination and treatment. A total of 64,515 valid questionnaires were collected. Among included participants, 5969 of which were asymptomatic. The symptoms were mainly upper respiratory symptoms, including dry and itchy throat (64.16%), sore throat (59.95%), hoarseness (57.90%), nasal congestion (53.39%). In binary Logistics regression model, we found that male, no pre-existing conditions, reinfection and vaccination have positive correlations with the appearance of asymptomatic COVID-19 patients. In Cox proportional-hazards regression model, considering all clinical symptoms disappeared in 14 days as outcome, we found that ≤ 60 years old, male, no pre-existing conditions, vaccination and adopted treatment have positive correlations with rapid amelioration of clinical symptoms in COVID-19 patients. The clinical symptoms of the participants were mainly upper respiratory symptoms which were according with the infection of Omicron variant. Factors including age, gender, pre-existing conditions and reinfection could influence the clinical characteristics and prognosis of COVID-19 patients. Importantly, vaccination has positive significance for the prevention and treatment of COVID-19. Lastly, the use of Chinese medicine maybe beneficial to COVID-19 patients, however, reasonable guidance is necessary.