%0 Journal Article
%T Prenatal origin of NUTM1 gene rearrangement in infant B-cell precursor acute lymphoblastic leukaemia.
%A Bardini M
%A Fazio G
%A Abascal LC
%A Meyer C
%A Maglia O
%A Sala S
%A Palamini S
%A Rebellato S
%A Marschalek R
%A Rizzari C
%A Biondi A
%A Cazzaniga G
%J Br J Haematol
%V 0
%N 0
%D 2024 Aug 5
%M 39099338
%F 8.615
%R 10.1111/bjh.19685
%X Rearrangement of NUTM1 gene (NUTM1r) is one of the most frequent aberrations occurring in infants (younger than 1 year at diagnosis) with B-cell precursor Acute Lymphoblastic Leukaemia (BCP-ALL). In this study we had the unique opportunity to analyze the umbilical cord blood (UCB) sample from one infant patient with NUTM1r BCP-ALL. Herein we reported for the first time that NUTM1r infant ALL arise prenatally, as both the patient-specific CUX1::NUTM1 fusion gene, as well as two IG/TR leukaemic markers were already present and detectable in the patient's UCB at birth. Our results clearly demonstrate the prenatal origin of NUTM1r infant BCP-ALL.