%0 Journal Article
%T Novel model of multiple sclerosis induced by EBV-like virus generates a unique B cell population.
%A Deffenbaugh JL
%A Jung KJ
%A Murphy SP
%A Liu Y
%A Rau CN
%A Petersen-Cherubini CL
%A Collins PL
%A Chung D
%A Lovett-Racke AE
%J J Neuroimmunol
%V 394
%N 0
%D 2024 09 15
%M 39098102
%F 3.221
%R 10.1016/j.jneuroim.2024.578408
%X Epstein-Barr virus (EBV) is deemed a necessary, yet insufficient factor in the development of multiple sclerosis (MS). In this study, myelin basic protein-specific transgenic T cell receptor mice were infected with murid gammaherpesvirus 68 virus (MHV68), an EBV-like virus that infects mice, resulting in the onset neurological deficits at a significantly higher frequency than influenza or mock-infected mice. MHV68 infected mice exhibited signs including optic neuritis and ataxia which are frequently observed in MS patients but not in experimental autoimmune encephalomyelitis mice. MHV68-infected mice exhibited increased focal immune cell infiltration in the central nervous system. Single cell RNA sequencing identified the emergence of a population of B cells that express genes associated with antigen presentation and costimulation, indicating that gammaherpesvirus infection drives a distinct, pro-inflammatory transcriptional program in B cells that may promote autoreactive T cell responses in MS.