%0 Journal Article
%T Successful rechallenge with azacytidine and venetoclax after sustained treatment-free remission in a relapsed acute myeloid leukemia patient: a case report.
%A Tamellini E
%A Simio C
%A Bernardelli A
%A Ferrarini I
%A Vatteroni A
%A Moioli A
%A Macaluso V
%A Marchetti E
%A Tanasi I
%J Ann Hematol
%V 0
%N 0
%D 2024 Aug 3
%M 39096371
%F 4.03
%R 10.1007/s00277-024-05922-6
%X Combined therapy with venetoclax and hypomethylating agents has significantly improved the outcome of unfit patients ineligible for intensive chemotherapy. A recently published exploratory analysis of the VIALE-A trial reported that up to 51% of patients achieving remission survived more than 2 years. These data along with those from reallife settings, lead to questioning how long it is appropriate to continue treatment in long-term survivors. Accordingly, recent retrospective studies suggested the feasibility of suspending therapy in selected patients while maintaining prolonged responses. Also, these studies showed that retreatment may induce a second remission in almost a third of patients. We report the case of a patient who received salvage therapy with venetoclax and azacytidine, that was discontinued few cycles after blasts clearance because of severe hematological toxicity. Despite suspension, he maintained a sustained response lasting almost one year and was successfully retreated with the same combination when a second relapse occurred.