%0 Journal Article
%T Cyclotron production of manganese-52: a promising avenue for multimodal PET/MRI imaging.
%A Porto F
%A Cisternino S
%A Cazzola E
%A Speltri G
%A Mou L
%A Boschi A
%A Marvelli L
%A Di Domenico G
%A Pagnoni A
%A De Dominicis L
%A Calliari I
%A Gennari C
%A Uccelli L
%A Pupillo G
%A Gorgoni G
%A Esposito J
%A Martini P
%J EJNMMI Radiopharm Chem
%V 9
%N 1
%D 2024 Aug 2
%M 39093479
暂无%R 10.1186/s41181-024-00288-6
%X <B>BACKGROUND: </B>The integration of positron emission tomography (PET) and magnetic resonance imaging (MRI) holds promise for advancing diagnostic imaging capabilities. The METRICS project aims to develop cyclotron-driven production of 52Mn for PET/MRI imaging.<BR><B>RESULTS: </B>Using the 52Cr(p,n)52Mn reaction, we designed chromium metal targets via Spark Plasma Sintering and developed a separation procedure for isolating 52Mn. Labeling tests were conducted with traditional chelators (i.e. S-2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid) and the 1.4-dioxa-8-azaspiro[4.5]decane-8- carbodithioate ligand to produce radioactive complexes suitable for PET/MRI applications. Our methodology yielded high-quality 52Mn suitable for PET radiopharmaceuticals and PET/MRI imaging. Preliminary studies on phantom imaging using microPET and clinical MRI demonstrated the efficacy of our approach.<BR><B>CONCLUSIONS: </B>The developed technology offers a promising avenue for producing 52Mn and enhancing PET/MRI imaging capabilities. Further in vivo investigations are warranted to evaluate the potential advantages of this hybrid imaging technique.