%0 Journal Article
%T Digital remote assessment of speech acoustics in cognitively unimpaired adults: feasibility, reliability and associations with amyloid pathology.
%A van den Berg RL
%A de Boer C
%A Zwan MD
%A Jutten RJ
%A van Liere M
%A van de Glind MABJ
%A Dubbelman MA
%A Schlüter LM
%A van Harten AC
%A Teunissen CE
%A van de Giessen E
%A Barkhof F
%A Collij LE
%A Robin J
%A Simpson W
%A Harrison JE
%A van der Flier WM
%A Sikkes SAM
%J Alzheimers Res Ther
%V 16
%N 1
%D 2024 Aug 1
%M 39090738
暂无%R 10.1186/s13195-024-01543-3
%X <B>BACKGROUND: </B>Digital speech assessment has potential relevance in the earliest, preclinical stages of Alzheimer's disease (AD). We evaluated the feasibility, test-retest reliability, and association with AD-related amyloid-beta (Aβ) pathology of speech acoustics measured over multiple assessments in a remote setting.<BR><B>METHODS: </B>Fifty cognitively unimpaired adults (Age 68 ± 6.2 years, 58% female, 46% Aβ-positive) completed remote, tablet-based speech assessments (i.e., picture description, journal-prompt storytelling, verbal fluency tasks) for five days. The testing paradigm was repeated after 2-3 weeks. Acoustic speech features were automatically extracted from the voice recordings, and mean scores were calculated over the 5-day period. We assessed feasibility by adherence rates and usability ratings on the System Usability Scale (SUS) questionnaire. Test-retest reliability was examined with intraclass correlation coefficients (ICCs). We investigated the associations between acoustic features and Aβ-pathology, using linear regression models, adjusted for age, sex and education.<BR><B>RESULTS: </B>The speech assessment was feasible, indicated by 91.6% adherence and usability scores of 86.0 ± 9.9. High reliability (ICC ≥ 0.75) was found across averaged speech samples. Aβ-positive individuals displayed a higher pause-to-word ratio in picture description (B = -0.05, p = 0.040) and journal-prompt storytelling (B = -0.07, p = 0.032) than Aβ-negative individuals, although this effect lost significance after correction for multiple testing.<BR><B>CONCLUSIONS: </B>Our findings support the feasibility and reliability of multi-day remote assessment of speech acoustics in cognitively unimpaired individuals with and without Aβ-pathology, which lays the foundation for the use of speech biomarkers in the context of early AD.