%0 Journal Article
%T Effect of Trehalose Disaccharide on Activation of Microglia and Indices of Systemic Inflammation in an Experimental Model of Alzheimer's Disease.
%A Zozulya SA
%A Akopyan AA
%A Tenditnik MV
%A Ovsyukova MV
%A Korolenko TA
%A Klyushnik TP
%A Tikhonova MA
%A Pupyshev AB
%J Bull Exp Biol Med
%V 177
%N 2
%D 2024 Jun 2
%M 39090471
%F 0.737
%R 10.1007/s10517-024-06157-1
%X In an experimental model of Alzheimer's disease in mice, oral administration of trehalose disaccharide reduces neuroinflammation assessed by the expression level of microglia activation marker Iba1 and affects the neutrophil degranulation activity. A potential anti-inflammatory effect of 4% trehalose solution associated with a decrease in the activity of leukocyte elastase in plasma was revealed.