%0 Journal Article
%T Systematic review and meta-analysis of transcranial direct current stimulation (tDCS) for global cognition in mild cognitive impairment and Alzheimer's disease.
%A Hou Y
%A Liu F
%A Su G
%A Tu S
%A Lyu Z
%J Geriatr Nurs
%V 59
%N 0
%D 2024 Jul 31
%M 39089145
%F 2.525
%R 10.1016/j.gerinurse.2024.07.013
%X <B>OBJECTIVE: </B>To systematically assess the effectiveness of transcranial direct current stimulation (tDCS) on global cognition in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD).<BR><B>METHODS: </B>Ten databases were retrieved for pertinent Chinese and English studies published up until February 2023.<BR><B>METHODS: </B>Two researchers independently selected the literature, extracted the data, evaluated using the Cochrane Collaboration's quality criteria, and then cross-checked. Meta-analysis was performed using RevMan 5.4.<BR><B>RESULTS: </B>22 studies involving 1074 patients were included. Compared with the control group received the interventions such as pharmacotherapy, cognitive stimulation, et al., with/without sham-tDCS, while the experiment group received tDCS added to the interventions of the control group. The meta-analysis found that tDCS increased MMSE, MoCA, MODA scores and reduced the P300 latency scores (all P < 0.05).<BR><B>CONCLUSIONS: </B>The tDCS can ameliorate the global cognition of patients with MCI and AD, and it has a better rehabilitation effect than non-tDCS or sham-tDCS.