%0 Review
%T Photo-activated microtubule targeting drugs: Advancing therapies for colorectal cancer.
%A Singh N
%A Sharma S
%J World J Gastroenterol
%V 30
%N 26
%D 2024 Jul 14
%M 39086641
%F 5.374
%R 10.3748/wjg.v30.i26.3257
%X Over the years immunotherapy has demonstrably improved the field of cancer treatment. However, achieving long-term survival for colorectal cancer (CRC) patients remains a significant unmet need. Combination immunotherapies incorporating targeted drugs like MEK or multi-kinase inhibitors have offered some palliative benefit. Nevertheless, substantial gaps remain in the current therapeutic armamentarium for CRC. In recent years, there has been a surge of interest in exploring novel treatment strategies, including the application of light-activated drugs in conjunction with optical devices. This approach holds promise for achieving localized and targeted delivery of cytotoxic agents, such as microtubule-targeting drugs, directly to cancerous cells within the colon.