%0 Journal Article
%T Fibroblast growth factor homologous factors: canonical and non-canonical mechanisms of action.
%A Goldfarb M
%J J Physiol
%V 602
%N 17
%D 2024 Sep 31
%M 39083261
%F 6.228
%R 10.1113/JP286313
%X Since their discovery nearly 30 years ago, fibroblast growth factor homologous factors (FHFs) are now known to control the functionality of excitable tissues through a range of mechanisms. Nervous and cardiac system dysfunctions are caused by loss- or gain-of-function mutations in FHF genes. The best understood 'canonical' targets for FHF action are voltage-gated sodium channels, and recent studies have expanded the repertoire of ways that FHFs modulate sodium channel gating. Additional 'non-canonical' functions of FHFs in excitable and non-excitable cells, including cancer cells, have been reported over the past dozen years. This review summarizes and evaluates reported canonical and non-canonical FHF functions.