%0 Journal Article
%T Global and multi-partition local network analysis of scalp EEG in West syndrome before and after treatment.
%A Liu L
%A Zheng R
%A Wu D
%A Yuan Y
%A Lin Y
%A Wang D
%A Jiang T
%A Cao J
%A Xu Y
%J Neural Netw
%V 179
%N 0
%D 2024 Jul 14
%M 39079377
%F 9.657
%R 10.1016/j.neunet.2024.106540
%X West syndrome is an epileptic disease that seriously affects the normal growth and development of infants in early childhood. Based on the methods of brain topological network and graph theory, this article focuses on three clinical states of patients before and after treatment. In addition to discussing bidirectional and unidirectional global networks from the perspective of computational principles, a more in-depth analysis of local intra-network and inter-network characteristics of multi-partitioned networks is also performed. The spatial feature distribution based on feature path length is introduced for the first time. The results show that the bidirectional network has better significant differentiation. The rhythmic feature change trend and spatial characteristic distribution of this network can be used as a measure of the impact on global information processing in the brain after treatment. And localized brain regions variability in features and differences in the ability to interact with information between brain regions have potential as biomarkers for medication assessment in WEST syndrome. The above shows specific conclusions on the interaction relationship and consistency of macro-network and micro-network, which may have a positive effect on patients' treatment and prognosis management.